domingo, 18 de enero de 2009

Testosterone replacement in postmenopausal women. Patient information.

Comment about the NEJM paper: Testosterone for low libido in postmenopausal women not taking estrogen.

Some important facts about the issue:

- Sexual desire is related with testosterone levels in men and women.
- Ovary, in menopausal women, produces less estrogens and androgens.
- In menopausal women dicrease in sexual desire is usual, entity that someone has named: "Hypoactive Sexual Desire Disorder".
- After a ovaries' surgery (removement) it has been demonstrated that testosterone replacement improves slightly but with statistical significance the sexual desire and frequency of sexual activity. However the safety profile is unknown in the long term.

A clinical trial was performed in menopausal women (non-surgical) to study the effect of testosterone replacement by patches in their sexual activity. These are the conclusions:

The replacement with 300 micrograms of testosterone in transdermical patches improves the frequency of sexual activity (from about 1 per 6 weeks to 2 per 4 weeks). However the safety profile in the long term is unknown and the treatment could be associated with breast cancer.

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